Our core SNAP technology assays the binding affinity and specificity of purified proteins or cell lysates on a microarray containing double-stranded, B-form DNA.

 

SNAPplications

 

• Designing therapeutics to disrupt transcription factor binding at a specific genomic location.

 

• Examining changes in specificity caused by a heterodimeric partner.

 

• Identifying functional SNPs that alter  transcription factor binding for personalized medicine applications. Adaptable to SNPs involved in any disease.

 

• Discovering the DNA-binding preferences of drug targets and novel or under-studied proteins.

 

• Screening test compounds that modulate the specificity of transcription factors in disease.  

 

• Complements ChIP-seq by defining direct DNA binding interactions.

 

• Solution-based high throughput screening of DNA binding specificity

 

• DNA and RNA SNAPtamer arrays for biomarker discovery